As a result, 154 overexpressed and 234 under-expressed genes were identified as common DEGs. In addition, the connectivity map was used for the prediction of potential drugs.
Protein–protein interactions (PPI) map were performed by STRING and fine-tuned by Cytoscape to screen the enriched gene module. Then, the ontology of the genes and the metabolic pathway enrichment analysis were carried out for the classified samples based on expression values. Gene expression datasets of GSE68848, GSE169158, and GSE4290 studies were collected and analyzed to identify the DEGs between the diseased and the control samples. Therefore, we intended to investigate the differentially expressed shared genes and therapeutic agents which are significant for these conditions by using in silico approaches.
The mechanisms underlying this comorbidity, including genomic interactions, tumor differentiation, immune responses, and host defense, are not completely explained. Glioblastoma cases have been reported to have increased during COVID-19. Glioblastoma (GBM) is a type of brain cancer that is typically very aggressive and difficult to treat.
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